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Molecular hydrogen is a medical gas that has been the subject of medical research for longer than you may have thought. The first publication linking molecular hydrogen and medicinal properties dates to 1798. Nearly 100 years later, in 1888, there was another publication, The Annals of Surgery, that referenced Dr. Nicolas Senn, who was using molecular hydrogen for medical applications. This slow progression of research proceeded with brief but powerful glimpses of molecular hydrogen's medical potential.

Hydrogen water

Molecular hydrogen offers remarkable medical potential

AUTHOR – Tywon Hubbard, cancertutor.com

In 1975, an impressive study demonstrated that hyperbaric molecular hydrogen therapy could be a possible treatment for cancer. In this study, the researchers showed that exposing mice with skin cancer (tumors) to 2.5 percent oxygen (O2) and 97.5 hydrogen (H2) for two weeks produced a dramatic and significant regression of the mice tumors. Here is a quote from the study:

“After a first 10-day period of exposure of the mice to the hydrogen-oxygen therapy it was found qualitatively (i) that the tumors had turned black, (ii) that some had dropped off, (iii) that some seemed to have shrunk at their base and to be in the process of being ‘pinched off,’ and (iv) that the mice appeared to suffer no deleterious consequences.”

Still, considering this amazing discovery, molecular hydrogen was believed by the scientific and medical community to be a biologically inert gas (meaning “having little to no effect in the human body”). This way of thinking by the scientific and medical community was flipped on its head in 2007 when a groundbreaking study demonstrated that molecular hydrogen is a selective antioxidant that neutralizes only the cytotoxic free radicals. The study was published in the prestigious Journal of Nature Medicine. The study showed that molecular hydrogen neutralizes the hydroxyl radical (OH*), the most cytotoxic free radical in existence, one that the human body has no natural defenses against, and converts it into water.

Since 2007, medical research on molecular hydrogen has exploded proving this gas has remarkable medical potential.

Research studies and reviews

Hydrogen has marked therapeutic potential to help with the top 8 fatality-causing diseases listed by the CDC.

The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance

Overall, the impact of molecular hydrogen in medicine is extraordinary. The non-toxic and rapid intracellular diffusion features of this biological gas ensure the feasibility and readiness for its clinical translation.

Molecular hydrogen: a therapeutic antioxidant and beyond

Recent publications revealed that, in addition to the direct neutralization of highly reactive oxidants, H2 indirectly reduces oxidative stress by regulating the expression of various genes. Moreover, by regulating gene expression, H2 functions as an anti-inflammatory, antiallergic, and antiapoptotic molecule, and stimulates energy metabolism. In addition to growing evidence obtained by model animal experiments, extensive clinical examinations were performed or are under way. Since most drugs act on their specific targets, H2 seems to differ from conventional pharmaceutical drugs. Owing to its great efficacy and lack of adverse effects, H2 has potential for clinical applications for many diseases.

Molecular hydrogen as a novel antioxidant: Overview of the advantages of hydrogen for medical applications

Understanding the basic effects

Molecular hydrogen is a selective antioxidant

Molecular hydrogen appears to be a selective antioxidant. Molecular hydrogen appears to also reduce a powerful oxidant, Peroxynitrite (ONOO-). This would mean that Molecular Hydrogen has the potential to protect our DNA/RNA and proteins from damage (oxidative stress). Importantly, it does this while not perturbing cellular homeostasis; H2 does not neutralize beneficial free radicals (NO, H2O2, etc) necessary for the body to function properly.

Molecular hydrogen is a Nrf2 activator

Molecular hydrogen appears to stimulate the production of endogenous antioxidants via the Nrf2 Pathway, meaning it up-regulates the body’s own antioxidant system. This results in the production of more protective enzymes (antioxidants) such as glutathione, catalase, and superoxide dismutase. These antioxidants are powerful and aid in the reduction of excessive ROS and oxidative-stress within the body, which have been linked to nearly all human diseases.

Molecular hydrogen is a signaling molecule/gene regulator

Molecular hydrogen appears to be a novel signaling molecule that participates in gene expression, cell modulation, and protein regulation. This means H2 can alter cellular signaling pathways resulting in benefits far beyond its antioxidant function. Research has demonstrated that molecular hydrogen can regulate inflammatory cytokines, hormones, proteins, and much more. Because of these properties, molecular hydrogen has the potential to give anti-inflammatory, anti-allergic, anti-cell death effects.

Research shows molecular hydrogen has the potential to exhibits these effects:

  • Anti-Inflammatory Effects
  • Smallest, most bioavailable molecule in existence
  • Selective antioxidant
  • Participates in Gene Expression
  • Anti-Allergic Effects
  • Anti-Aging
  • Reduces aches and pains
  • Protective to skin
  • Cardioprotective
  • Increases Metabolism
  • Increases Body's Antioxidants (Nrf2 activator)
  • Decreases Muscle Fatigue
  • Reduces Lactate Levels
  • Anti-Diabetic Effects (type 1 and 2)
  • Anticancer
  • Improves Cognitive Function
  • Protects DNA & RNA
  • Anti-Tumor Effects
  • Cytotoxic Protection
  • Neuroprotective
  • Radiation Protection
  • With zero toxic effects

Based on scientific studies/evidence, hydrogen gas therapy has the potential to benefit:

See the full list of studied conditions
  • Alzheimer's
  • arthritis
  • rheumatoid arthritis
  • Type 1 diabetes
  • Type 2 diabetes
  • Parkinson's
  • COPD
  • asthma
  • heart disease
  • kidney disease
  • stroke
  • cancer
  • tumors
  • ALS
  • dementia
  • psoriasis
  • dermatitis
  • IBS
  • hemorrhagic shock
  • Crohn's
  • fatty liver disease
  • liver cirrhosis
  • pancreatitis
  • cardiac arrest
  • neuropathy
  • Multiple Sclerosis
  • Hepatitis B
  • atherosclerosis
  • cataracts
  • hypertension
  • gum disease
  • traumatic brain injury
  • sepsis
  • subarachnoid hemorrhage (aneurysms)
  • infant lung disease
  • metabolic syndrome
  • lymphoma
  • retinitis
  • painful bladder syndrome
  • osteosclerosis
  • osteoarthritis
  • osteoporosis
  • glaucoma
  • pulmonary hypertension
  • pulmonary fibrosis
  • autism
  • depression
  • bipolar disorder
  • anxiety
  • schizophrenia
  • inflammation
  • muscle fatigue
  • increased ATP production
  • soft tissue injuries
  • pain
  • wounds
  • burns
  • seasonal allergies
  • autoimmune disorders
  • insulin resistance
  • hearing loss
  • ulcers
  • radiation damage

…to name just a few as there are studies on over 170 human disease models

Molecular hydrogen’s therapeutic potential is enormous and the research is still in its infancy. It’s not every day that a therapeutic agent like this comes along with this much scientific backing and medical potential. On top of that, one of the most effective ways of consuming it is dissolved into the life-giving solvent: water.

To learn more about molecular hydrogen or hydrogen water’s potential health benefits and to see supporting scientific research visit:

Tywon Hubbard is an independent educator of scientific and medicinal research dedicated to helping, serving, and educating the world about molecular hydrogen’s potential therapeutic benefits. He studied corporate fitness at the University of Central Missouri. Studying under leading experts in the field, Tywon’s expertise in molecular hydrogen led him to be the first in the world to receive the Level 3 MHF (Molecular Hydrogen Foundation) Professional Certification.

Tywon Hubbard